build your PK model
[LONGITUDINAL] input = {Tk0, V, k12, k21, k13, k31, Vm, Km} EQUATION: cc = pkmodel(Tk0, V, k12, k21, k13, k31, Vm, Km)
adm <- list(time = c(1,23,37,45), amount = c(1,0.5,2,0.3)) p <- list(name=c('Mtt', 'Ktr', 'ka', 'V', 'Vm', 'Km', 'p'), value=c(5, 1, 0.5, 10, 1, 0.6, 0.5)) t <- seq(0, 80, by=0.1) res <- pkmodel(t,adm,p) pl=ggplot(data=res, aes(x=time, y=cc)) + geom_line(size=1) + xlab("time (h)") + ylab("concentration (mg/L)") print(pl)
Select the administration route and the dosage regimen in the tab administration:
Define the PK model in the tab model:
Define the absorption process for oral administration in the tab absorption:
Define the distribution process in the tab distribution: 1, 2 or 3 compartments
Define the eliination process in the tab elimination: linear or Michaelis Menten elimination process
Define the output in the tab outputs:
Set some settings in the tab settings: line width, linear or semi-log scale.